Work

Metabolic signature combined with changes in proteome and transcriptome shape respiratory syncytial virus infection and response to vaccination in a bovine model

Year: 2026

Type: article

Abstract: = 4/group), we identified a complement and innate immune protein signature in NV calves that aligned with metabolic features. In lesioned lung tissue, immune engagement between V and NV calves differed with changes observed in multiple metabolites that tightly correlated with gene expression and showed higher inflammatory cytokine gene expression (IL17A, IL6, IFNγ, IFNβ, IL8) in NV calves. Collectively, our data show an integrative approach enables a comprehensive molecular view of translationally relevant biointerfaces to understand vaccination and reinfection-associated host response. The outcomes of this study can be leveraged in the long-term to understand treatment response in human RSV.

Source: RSC Advances

DOI: 10.1039/d6ra06302k