Year: 2026
Type: article
Abstract: Annually, millions of humans and animals suffer from chronic and acute pain, creating welfare and quality of life concerns for both humans and animals. There is a need to develop new and effective analgesic options as alternatives to opioids and non-steroidal anti-inflammatories (NSAIDs) for humans and animals. A major challenge in developing novel therapeutic approaches is accurately measuring the impact of pain in animal models in a way that is clinically relevant and predictive of clinical efficacy. The Pain in Animals Workshop (PAW) meetings are held every other year in partnership with the National Institutes of Health (NIH), bringing key stakeholders together to improve our understanding of the impact of pain in humans and animals and determine how best to measure this impact. The 2025 workshop explored the following topics: - Current perspectives on non-rodent models, - Artificial intelligence applied to the measurement of pain, - Evolutionary clues to pain mechanisms and novel measures, - Breed and sex differences in pain sensitivity (perceptions and reality). The workshop brought together academic, government, and industry experts. Under the topic of ‘Current perspectives on non-rodent models’, current views regarding such models were discussed, whilst also showcasing and discussing recent NIH funded/ongoing programs involving these models. With the current interest in non-rodent models and spontaneous disease models, the discussion on successes and challenges was timely. Given the topic's importance and the meeting's uniqueness, this narrative summarizes the presentations and discussions on the topic of current perspectives on spontaneous and other non-rodent disease models.
Source: Frontiers in Pain Research
Institutions: The University of Texas at Dallas, National Institutes of Health, National Institute of Neurological Disorders and Stroke, University of North Carolina at Chapel Hill, University of North Carolina Health Care, The University of Texas MD Anderson Cancer Center, North Carolina State University, Kansas State University, Center for Veterinary Medicine, United States Food and Drug Administration, Duke University
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,077
OpenAlex ID: W7225773338