OpenDrive: An Open-Source Microdrive for Large-Scale Neurophysiology
Year: 2026
Type: preprint
Abstract: Neuropixels-NHP probes have ushered in a new era of high-density neurophysiology recording in large animal models. Here, we present OpenDrive, an open-source microdrive system designed specifically for acute insertion of Neuropixels-NHPs. OpenDrive combines a custom motorized microdrive, six-drive control console, and software platform. Compared with commercially available options, OpenDrive offers (1) low cost, (2) precise, accurate, and stable probe movement, (3) scalability to many-probe recording, and (4) open-source hardware designs and software. In our experiments, OpenDrive has already supported recordings from thousands of neurons across a variety of cortical and subcortical structures. By lowering technical barriers and enabling community-driven development with OpenDrive, we aim to accelerate Neuropixels recording in large animal models.
Institution: Massachusetts Institute of Technology
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225784453
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