Year: 2026
Type: article
Abstract: Relevance. Infertility has many causes, and periodontal disease is being investigated as a potential factor associated with impaired female reproductive function. This is because inflamed periodontal tissues may release periodontal pathogens, their components, and proinflammatory mediators into the systemic circulation. Objective. To systematically review the evidence on periodontal status in patients undergoing assisted reproductive technology (ART) and its association with reproductive outcomes. Materials and methods. This systematic review was conducted in accordance with the PRISMA 2020 reporting guidelines. PubMed, ScienceDirect, Google Scholar, and CyberLeninka were searched for publications dated from 1967 through July 6, 2026. Of the 3.814 publications identified, 714 were selected for screening and 251 for full-text assessment; 95 were included in the review. The review evaluated studies on periodontal status in patients with infertility and during infertility treatment, studies on associations of periodontal disease with fertility and reproductive outcomes, and experimental studies. Methodological quality and risk of bias were assessed using JBI, RoB 2, ROBINS-I, SYRCLE, and AMSTAR/AMSTAR 2. Because of study heterogeneity, a qualitative synthesis was performed. Results. Periodontal status worsened during infertility treatment and in vitro fertilization (IVF), primarily because of increased gingivitis severity. Changes were more pronounced with prolonged hormonal exposure, preexisting gingivitis, or periodontitis. Individual studies reported associations of periodontal disease and periodontal, microbiological, and immunological parameters with female fertility. Evidence on associations between periodontal status and embryological parameters, pregnancy, and live birth after ART is limited and heterogeneous. Clinically evident periodontitis in patients undergoing ART has not been adequately studied. Conclusion. Periodontal status may influence reproductive function. The implications of this association for ART outcomes warrant further study.
Source: Parodontologiya
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7225800740