Work

Hepatic sinusoidal obstruction syndrome and the search for a modifiable endothelial state

Year: 2026

Type: article

Abstract: Pyrrolizidine alkaloid (PA) exposure, haematopoietic stem cell transplantation (HSCT), and repeated oxaliplatin treatment provide distinct contexts for sinusoidal endothelial injury, with differing mechanisms and courses. Oxaliplatin-associated abnormalities may resolve or persist. Illustrated features are conceptual, not validated clinical stages or a shared temporal sequence. Recognition varies by setting and age; the proposed gap remains unvalidated. Current biomarkers and imaging do not establish the reversibility of liver sinusoidal endothelial cell (LSEC) injury. Clinical care remains etiology-specific. Testing whether an endothelial profile can guide treatment selection requires endothelial-associated measures, independent vascular assessment, and prospective evidence of differential treatment benefit. No endothelial-state-based treatment threshold has been validated.

Source: iMeta

DOI: 10.1002/imt2.70190

Authors: Ziming Zhao, Zijun Zhang, Fengling Liu, Haolu Wang, Di Yu, Chuanrui Xu, Xin Chen, Yang Xiao, Qing Yu, Qianrong Xiong, Eric C.H. Lai, Qingyi Tong, Xiaoping Chen, Yonghui Zhang

Institutions: Huazhong University of Science and Technology, The University of Queensland, Prince Charles Hospital, Tongji Hospital, University of Hawaii Cancer Center, Pamela Youde Nethersole Eastern Hospital

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,320

OpenAlex ID: W7225809254

FWCI:

Cites: 20

Cited by:

Related to: