Uncovering new antibiofilm roseabols from marine Clonostachys rosea through structural and multiomics approaches
Year: 2026
Type: article
Abstract: Through a combined approach, that involved the one-strain-many-compounds (OSMAC) culturing approach, metabolomic and genomic studies, and bioassay-guided purification we disclose the marine fungus Clonostachys rosea as producer of a family of peptaibols with new structural features. HRMS/MS, NMR, and advanced Marfey’s analysis enabled the structural elucidation of two major compounds of the roseabol family, named roseabols B ( 1 ) and C ( 2 ). Molecular networking further revealed a highly diverse and microheterogeneous peptaibol profile. Biological evaluation highlighted the ability of the isolated peptaibols to inhibit biofilm formation against Escherichia coli and Candida albicans . Overall, these studies demonstrate the effectiveness of metabolomics-driven strategies in discovering novel natural products and identify marine-derived peptaibols as promising antibiofilm agents.
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7225811042