Acute Nitrobenzene Poisioning With Methemoglobinemia Managed With Methylene Blue
Year: 2026
Type: article
Abstract: Nitrobenzene poisoning is rare but can be lethal. Tissue hypoxia results from the oxidation of haemoglobin to methaemoglobin. We describe a 26-year-old male who purposefully consumed roughly 30 millilitres of a nitrobenzene-containing beverage, resulting in giddiness and recurrent vomiting. He had central cyanosis, a bluish tongue, and was awake (GCS E4V5M6) Heart rate was 123 bpm, respiratory rate 22/min, blood pressure 150/90 mmHg, and SpO₂ 78–83% on room air. ECG showed sinus tachycardia. He was started on high-flow oxygen (15 L/min) and admitted to the ICU. He was treated with IV methylene blue [50mg in 100 ml NS over 15min, stat] and supportive care. He recovered by day and was discharged. Early recognition of nitrobenzene toxicity in patients with cyanosis and low SpO₂, with prompt methylene blue and supportive care, is crucial for a good outcome.
Author: Bindushree J K, Shreyas Gowda P
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225832836
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