Work

Evidence for a Physiologic Role of Erythropoietin in Fetal Erythropoiesis

Year: 1974

Type: article

Abstract: Administration of antibody prepared in rabbits against human urinary Ep to fetal sheep during the last third of the gestation period resulted in a suppression of erythropoiesis in the fetus. This was evidenced by a sharp decrease in the numbers of circulating reticulocytes and a reduced rate of 59Fe incorporation into RBC, spleen, and bone marrow, effects ascribable to a neutralization of endogenous Ep. In addition, there was a significant decrease in the numbers of nucleated erythroid cells in the bone marrows of these fetuses. These results point to a physiologic role for Ep in fetal erythropoiesis.

Source: Blood

DOI: 10.1182/blood.v44.2.285.285

Authors: Esmail D. Zanjani, Leon I. Mann, Harold Burlington, Albert S. Gordon, Louis R. Wasserman

Institutions: City University of New York, New York University, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, U.S. Public Health Service