Work

Expression of Dnmt1, Dnmt3a, Dnmt3b and HMT in different colonic cancer cell lines and its significance

Year: 2008

Type: article

Abstract: 目的：探讨不同结肠癌细胞系中表观遗传学酶谱的表达水平．方法：RT-PCR分别检测结肠癌细胞系HT-29、Lovo和Caco-2和Dnmt1、Dnmt3a、Dnmt3b和HMT mRNA表达水平．结果：Dnmt3b mRNA在结肠癌细胞HT-29、Lovo中高度表达，Dnmt1与HMT次之，Dnmt3a表达水平最低；Dnmt3b、Dnmt3a在不同结肠癌细胞系之间的表达水平存在显著的差异．结论：不同分化程度的结肠癌细胞系可能存在不同的表观遗传学发生机制；Dnmt3b在建立和维持结肠癌细胞系DNA甲基化模式中可能起更为重要的角色．

Source: World Chinese Journal of Digestology

DOI: 10.11569/wcjd.v16.i4.426

Authors: Rong-Lin Zhai, Kai-Lin Cai, Guo-Bin Wang, Fei Xu, Yuan Tian, Jing-Hui Zhang

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W745846942

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