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Pharmacokinetics of FK 506 following oral administration: a comparison of FK 506 and cyclosporine.

Year: 1991

Type: article

Abstract: F K 506 is currently used as the primary immunosup- pressant in.over 800 organ tra~splant pati~nts at ~e University of Pittsburgh.FK 506 IS a macrolide and IS chemically very different from any other immunosuppressive drug used currently in transplant patients.Howe .. cr, FK 506 is very similar to cyclosporine (Cy A) in a numt-er of physicochemical properties and its mechanism of action (Table 1).1.2The objective of the present study is to determine the pharmacokinetics of FK 506 after oral administration.to compare its kinetic properties 1oI.ith erA.and to discuss the clinical relevance of the differences in the kinetic properties. DOSAGE FORMFK 506 was administered to patients as an IV infusion over 2 to 4 hours or as a continuous infusion over 24 hours.For oral administration.a hard gelatin capsule containing a 20% solid dispersion of FK 506 in hydroxy propyl methyl cellulose and HCHO 60 was used.

Source: PubMed