Year: 2013
Type: article
Abstract: Glucocorticoids (GCs) are the most potent, and widely used anti-inflammatory agents known.Despite their wide therapeutic use over many years much remains unclear about how GCs mediate their broad spectrum of cellular effects.The reasons why some patients fail to respond to GCs are also poorly understood.GCs mediate their cellular effects through the glucocorticoid receptor (GR) which is a ligand activated transcription factor.After binding GC, GR translocates to the nucleus to modulate transcription either by direct DNA binding (transactivation), or by tethering to other DNA bound transcription factors such as AP1 and NF-kB (transrepression).
Author: Nan Yang
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W753883436