Work

G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease.

Year: 2014

Type: article

Abstract: G protein signaling modulator-3 (GPSM3), also known as G18 or AGS4, is a member of a family of proteins containing one or more copies of a small regulatory motif known as the GoLoco (or GPR) motif. GPSM3 interacts directly with Gα and Gβ subunits of heterotrimeric G proteins to regulate downstream intracellular signals initiated by G protein coupled receptors (GPCRs) that are activated via binding to their cognate ligands. GPSM3 has a selective tissue distribution and is highly expressed in immune system cells; genome-wide association studies (GWAS) have recently revealed that single nucleotide polymorphisms (SNPs) in GPSM3 are associated with chronic inflammatory diseases. This review highlights the current knowledge of GPSM3 function in normal and pathologic immune-mediated conditions.

Source: Europe PMC (PubMed Central)

Authors: Matthew J Billard, Bryan J Gall, Kristy L Richards, David P Siderovski, Teresa K Tarrant

Institutions: University of North Carolina at Chapel Hill, West Virginia University, West Virginia Clinical and Translational Science Institute, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Modeling Lymphocyte Chemokine Receptor Dynamics and Polarization Signals, Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling, G protein-coupled receptor kinase 3 regulation of leukocyte function in inflammat, West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health