Work

Sustained Negative BOLD and Blood Flow Response and its Coupling to the Positive Response in the Human Brain

Year: 2002

Type: other

Abstract: Most fMRI studies are based on the detection of a positive BOLD response (PBR). A few previous human studies indicated the existence of negatively responding voxels in brain regions remote from the focus of PBR (1, 2, and others). Recent studies in the anesthetized cat (3) and monkey (4) have demonstrated adjacent PBR and negative BOLD response (NBR). In this study we demonstrate sustained (different from the "initial dip") negative BOLD response (NBR) that occurs concurrently with and is coupled to the positive response, via a mechanism that involves a reduction in blood flow (CBF) to the less demanding regions in the human brain.

Source: MPG.PuRe (Max Planck Society)

Authors: Amir Shmuel, Pfeuffer Yacoub E, Adriany G Van de Moortele P-F, Xiaoping Hu

Institutions: Max Planck Society, Max Planck Institute for Biological Cybernetics

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W758096833

Cites:

Cited by: 20

Related to: 10