Year: 2011
Type: dissertation
Abstract: Substantial evidence has demonstrated that dendritic protein synthesis is an important source of new protein during the expression of synaptic plasticity.Dendritically synthesized brain-derived neurotrophic factor (BDNF) has been shown to be key in the expression of lasting synaptic plasticity.However little is known about the function of dendritic protein synthesis in other cellular forms of plasticity.Here we investigated the role of dendritic BDNF synthesis in adult neurogenesis and spine morphogenesis.Adult neurogenesis in the subgranular zone (SGZ) of the dentate gyrus is regulated by hippocampal network activity.However the interplay between
Author: Emily G. Waterhouse
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W762790947