Work

The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals [Short communication]

Year: 2013

Type: article

Abstract: Isoniazid preventive therapy (IPT) is recommended in patients on antiretroviral treatment. Isoniazid (INH) inhibits CYP3A4, which metabolises nevirapine (NVP). Administration of INH may cause higher NVP concentrations and toxicity. We studied the effect of INH on NVP concentrations in 21 patients randomised to either placebo (n = 13) or INH (n = 8) in an ongoing trial of IPT in patients on ART. INH was associated with a 24% increase in median NVP area under the plasma concentration-time curve for the 12 h dosing interval, which was not statistically significant (P = 0.66).

Source: The International Journal of Tuberculosis and Lung Disease

DOI: 10.5588/ijtld.12.0427

Authors: E. H. Decloedt, J. Mwansa-Kambafwile, J-S. van der Walt, H. McIlleron, P. Denti, P. Smith, L. Wiesner, M. Rangaka, R. J. Wilkinson, G. Maartens

Institutions: University of Cape Town, Groote Schuur Hospital, Institute of Infectious Disease and Molecular Medicine, Imperial College London, Medical Research Council

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: World Health Organization, Wellcome Trust, National Institute for Health and Care Research, South African Medical Research Council, National Institutes of Health, U.S. Public Health Service, Fogarty International Center

Awards: G169754964, Quadruple intervention against tuberculosis., G2656862973, G76681233, G8687754615, Establishment of a Centre for Clinical Infectious Diseases Research at the University of Cape Town (Wellcome-UCT-CCIDR).

OpenAlex ID: W763515031

FWCI: 0.897

Cites: 8

Cited by: 15

Related to: 10