Updates of the Renin‐angiotensin‐aldosteron System
Year: 2013
Type: article
Abstract: The renin‐angiotensin‐aldosteron system (RAAS) is a hormonal system that contributes to regulation of blood pressure and volume of extracellular fluids, in both nor‐ motensive and hypertensive individuals. Hypertension affects the target organs (kidneys) and leads to a vicious circle that contributes to maintaining a high arterial pre‐ ssure. Besides the hemodynamic effects of RAAS/Ang II, Ang II has direct impact on structure/function of kidneys, leading to renal injury. Recently, the proinflammatory effect of Ang II has been discovered. Low renal inflamma‐ tion determined by excessive circulating RAAS, mostly at renal level, promotes and continues the renal disease. This review presents the inflammatory mechanisms initiated by Ang II at renal level, which induce development of renal injury. Identification of such mechanisms might lead to the discovery of new therapeutic approaches for hyperten‐ sion/target organs damage.
Authors: Minela MĂRĂNDUCA, P. PLĂMĂDEALA, Nina ZAMOSTEANU, B. STOICA, Elena STEFANACHI
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W777067053