Year: 2007
Type: dissertation
Abstract: Most research has been conducted on the structure and function of many individual genes as well as complementary proteins. Many of these studies look at specific population groups' country of origin, geographic location, or ethnicity but do not correlate findings between these groups. In this project I attempted to associate the structural and functional consequences of individual mutations in Human BRCA1 to other organisms. My findings suggest a strong correlation between human geographical isolation and mutation exclusivity. Furthermore strong sequence and mutation conservation as well as structural homology exist between many species.
Author: Matthew Gary Wronkowski
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W779744478