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Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors

Year: 2015
Type: article
Abstract: Micelles have been employed to encapsulate the supramolecular assembly of quantum dots with palladium(II) porphyrins for the quantification of O2 levels in aqueous media and in vivo. Förster resonance energy transfer from the quantum dot (QD) to the palladium porphyrin provides a means for signal transduction under both one- and two-photon excitation. The palladium porphyrins are sensitive to O2 concentrations in the range of 0-160 Torr. The micelle-encapsulated QD-porphyrin assemblies have been employed for in vivo multiphoton imaging and lifetime-based oxygen measurements in mice with chronic dorsal skinfold chambers or cranial windows. Our results establish the utility of the QD-micelle approach for in vivo biological sensing applications.
DOI: 10.1021/jacs.5b04765
Authors: Christopher M. Lemon, Elizabeth Karnas, Xiaoxing Han, Oliver T. Bruns, Thomas J. Kempa, Dai Fukumura, Moungi G. Bawendi, Rakesh K. Jain, Dan G. Duda, Daniel G. Nocera
Language: English
Subfield: Bioengineering
Open Access status: green
Awards: Nitric Oxide in Tumor Angiogenesis, Microcirculation and Radiation Therapy, G404075911, G446986368, Integrative Pathophysiology of Solid Tumors, G568228518, Probing Tumor Microenvironment Using Nanotechnology, G8862138839
OpenAlex ID: W785040517
FWCI: 14.66
Cites: 98
Cited by: 113
Related to: 10