Bupivacaine Release from Biopolymeric Depots for the Alleviation of Postoperative Pain
Year: 2000
Type: book-chapter
Abstract: The objective of this study is to develop an improved dose form for the longer-term delivery of a combined local—systemic system for pain management in an emergency situation. The amelioration of pain associated with injury (automobile accidents, industrial accidents, battlefield scenario, and so on), when treated with potent narcotic analgesics, may be associated with sedation and possible side effects, such as dizziness and nausea. Thus, functional activity may be reduced for as long as pain relief is necessary. Nevertheless, the opiate analgesics have an important role that cannot always be filled by local anesthetics (LAs). However, when pain is severe and long-lasting, it may be desirable to couple a narcotic with a LA. The side effects may be minimized, and long-lasting relief may be achieved, by controlled-release implants for delivery of either or both types of agent. Such anesthetic formulations may be implanted at the wound site, for local delivery of drug. Analgesic formulations may likewise be implanted at alternative, nontraumatized sites, for systemic delivery of drug. By use of a biodegradable excipient, poly(d,l-lactide-co-glycolide) (PLGA), the implants need not be removed, and drug delivery can be adjusted to address targeted deliveries from several days to approx 2 wk, using one long-acting dose form.
Source: Humana Press eBooks
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W78769005