Year: 2015
Type: other
Abstract: Background: 1) Control of the mitochondrial ATP production by SR-derived Ca2+ signals includes local, nanodomain Ca2+ transfer from ryanodine receptors (RyR2) to the mitochondrial matrix (excitation-bioenergetics coupling). 2) Ca2+ crosses the inner mitochondrial membrane (IMM) via the mtCU, a low-affinity Ca2+-activated Ca2+ channel complex. 3) The surface area of cardiac IMM is extensively enhanced by cristae folding; however, mitoplast patch clamp studies showed mtCU current density the lowest amongst a range of tissues (Fieni 2012. Nat Commun).
Source: The Medicine Forum
Authors: Sergio de la Fuente, Caitlin Vail, Elorm J. Agra, Kira M. Holmström, Junhui Sun, Jyotsna Mishra, Toren Finkel, Elizabeth Murphy, Shey‐Shing Sheu, György Csordás
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W803965631