Year: 2010
Type: dissertation
Abstract: (pdf)Schizophrenia is a severe mental disorder affecting 0.5-1% of the population worldwide.The disorder is characterized by positive symptoms, such as hallucinations, delusions and disorganized behavior and speech, and negative symptoms including avolition, anhedonia and flattened affect.Genetic factors have shown involvement in the etiology of schizophrenia.Based on family, twin and adoption studies, hereditability estimates reach 83 %.The genetic etiology of the disorder is complex with evidence for multiple genes and pathways contributing to the onset of the disorder Many promising candidate genes for schizophrenia have been suggested.In 2000 a novel gene, Disrupted in Schizophrenia 1 (DISC1) was recognized at the translocation breakpoint between chromosomes 1 and 11 (t(1;11)(q42.1;q14.3)) in a large Scottish family with the high prevalence of schizophrenia and other psychiatric disorders.Since, DISC1 has emerged as one of the most promising candidate genes for schizophrenia and other psychiatric disorders based on linkage and association studies and animal models.DISC1 is also shown to associate with schizophreniarelated cognitive, memory and neuroimaging phenotypes.
Source: Työväentutkimus Vuosikirja
Author: Liisa Tomppo
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W814555530