Cross talk between DNA repair and chromatin modifciations
Year: 2013
Type: dissertation
Abstract: The integrity of genome is constantly challenged by various endogenous and exogenous agents present in the environment. These damaging agents induce a variety of DNA lesions. DNA damage severely affects the cellular function such as DNA replication and gene transaction, causing cell cycle arrest, chromosomal aberrations during cell division. To counteract these harmful threats, cells have evolved with sophisticated DNA repair systems to troubleshoot DNA damage and guard the genome. Failure to repair such lesions leads to mutations, cell death and genomic instability.
Author: Karthikraj Karthikraj
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W82103952