Work

Cell Fate Decisions in Early Embryonic Development

Year: 2013

Type: dissertation

Abstract: The basis of developmental biology lies in the idea of when and how cells decide to divide or to differentiate. Previous studies have established several signaling pathways that determine cell fate decisions, including Notch, Wingless, Hedgehog, Bone morphogenetic protein, and Fibroblast growth factor. Signaling converges on transcriptional factors that regulate gene expression. In mouse embryonic stem cells, I explored how pluripotency and differentiation are regulated through opposing actions of beta-catenin-mediated canonical Wnt signaling, and the mechanisms underlying Sonic hedgehog signaling in generating progenitor cells in the ventral neural tube.

Source: Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Author: Xiaoxiao Zhang

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Nakatomi Foundation, Daiwa Securities Health Foundation, National Institutes of Health, Harvard Stem Cell Institute, Japan Society for the Promotion of Science

Award: Identification of osteogenic transcriptional networks by chromatin immunoprecipitation sequencing and genetic approaches

OpenAlex ID: W82720350

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