PPAR-g Regulatory Networks in Bone Metabolism And Mineralization
Year: 2015
Type: dissertation
Abstract: __Abstract__ \n \nBone is a highly dynamic tissue that is permanently remodeled as an intrinsic mechanism \nto regenerate bone during life, to accomplish longitudinal growth, and to generate new bone \nduring fracture repair. As bone formation must match closely the amount of bone that is \nresorbed at each site, bone remodeling is controlled by the coupled actions of osteoclasts \nand osteoblasts. Osteoblasts control the formation and activity of osteoclasts that are \nresponsible for the initiation and execution of resorption at remodeling sites. The bone resorbed \nby osteoclasts is replaced through the differentiation and activity of osteoblasts. This \ncoupling of the two processes is essential for bone balance. Due to age, sex hormone status, \ncancer and a variety of diseases associated with an activation of the immune system, the balance \nbetween bone resorption and formation can be shifted leading to local or systemic bone \nloss that ultimately results in osteoporosis. Osteoporosis is a prevalent skeletal disorder \nin the elderly that is characterized by impaired bone strength and increased fracture risk. It \nis associated with reduced life quality and increased mortality. On the other hand, excessive \nbone formation can give rise to sclerosing bone disorders that include many rare and \noften hereditary osteochondrodysplasias (e.g. osteopetrosis, Van Buchem disease and sclerosteosis), \nbut can also be caused by a variety of dietary, metabolic, endocrine, hematologic, \ninfectious or neoplastic disorders.
Author: Claudia Bruedigam
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W832470632