Targeting the Apoptotic Machinery as a Potential Antileukemic Strategy
Year: 2003
Type: book-chapter
Abstract: Apoptosis is a morphologically and biochemically distinctive cell death process that occurs under several physiologic and pathologic conditions (1,2). Morphologically, apoptosis is characterized by plasma membrane blebbing followed by chromatin condensation and disassembly of the cell into multiple membrane-enclosed fragments, which are then engulfed by neighboring cells or professional phagocytes (2). These biochemical changes are believed to reflect, at least in part, the action of caspases, unique intracellular proteases that digest critical polypeptides required for cellular integrity and survival (3,4).
Source: Humana Press eBooks
Authors: Benjamin M. F. Mow, Scott H. Kaufmann
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W8327150