Work

Regulation of T helper function by the microenvironment: role of hypoxia and ATP metabolism

Year: 2014

Type: dissertation

Abstract: In this work, we were interested in studying the effect of two main metabolic factors, hypoxia and extracellular ATP metabolism, on the effector function of T helper subsets. The major oxygen sensor is HIF-1α which is continuously degraded in the presence of oxygen but is stabilized in hypoxia, leading to transcription of genes involved in cellular adaptation to low oxygen level. Our data show that the proportion of IFN-&

Source: Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles)

Authors: Hussein Shehade, Muriel Moser, Guillaume Oldenhove

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W840782768

Cites:

Cited by:

Related to: 10