Studies of the genetic epidemiology of cardiovascular disease: focus on inflammatory candidate genes
Year: 2008
Type: dissertation
Study design: Observational Study
Abstract: Cardiovascular disease (CVD) is a complex disease with multifactorial aetiology.Both genetic and environmental factors contribute to the disease risk.The lifetime risk for CVD differs markedly between men and women, men being at increased risk.Inflammatory reaction contributes to the development of the disease by promoting atherosclerosis in artery walls.with fibrinogen levels.The results from this third study suggest a role for the interleukin 6 pathway genes in the pathogenesis of CVD and warrant further studies in other populations.In addition to the IL6 -related genes, we describe in this thesis several sex-specific associations in other genes included in this study.The majority of the findings were evident only in women encouraging other studies of cardiovascular disease to include and analyse women separately from men.
Source: Työväentutkimus Vuosikirja
Author: Mervi Alanne
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Award: G6091493096
OpenAlex ID: W844997472