Synthesis of Nanogel Carriers for Delivery of Active Phosphorylated Nucleoside Analogues.
Year: 2004
Type: article
Abstract: Effective in chemotherapy of cancer and viral infections nucleoside analogues are actually ‘prodrugs’, which must be first converted in vivo into nucleoside 5′-monophosphates and, finally, into the drugs active form, nucleoside 5′-triphosphates (NTPs). They efficiently terminate DNA synthesis and are cytotoxic for the proliferating cancer cells. However, therapeutic nucleoside analogues in form of 5′-triphosphates are considered too unstable as a drug form to be used directly in cancer chemotherapy. A new drug formulation, which is presented here, is based on NTPs encapsulated into the nanosized cross-linked cationic polymer network called Nanogel [1]. Previously, these carriers were proved to be useful for encapsulation of antisense oligonucleotides and low soluble hydrophobic drugs [2–3].
Source: PubMed
Authors: Serguei V Vinogradov, Alexander V Kabanov
Institution: University of Nebraska Medical Center
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funder: National Institutes of Health
OpenAlex ID: W85298361