Work

Cytotoxicity of gemcitabine-loaded thermosensitive liposomes in pancreatic cancer cell lines.

Year: 2015

Type: article

Abstract: cytotoxicity of GEM-TSLnps + mHT treated pancreatic cancer cell lines was significantly higher than GEM treated. The IC50 values for PANC-1, MiaPaCa-2 and BxPC-3 cells GEM-TSLnps + mHT treated were 1.2 to 3.5 fold-higher than GEM treated. Among the cell lines, GEM-TSLnps + mHT treated PANC-1 and MiaPaCa-2 cells show significantly reduced reproductive viability compared with the GEM treated cells. Flow cytometric and confocal images revealed high Rho-TSLnps cellular uptake. Our findings suggest that GEMTSLnps+ mHT can significantly enhance cytotoxic effect of GEM and could serve as a new chemotherapy modality for delivering GEM.

Source: PubMed

Authors: Kevin Affram, Ofonime Udofot, Edward Agyare

Institution: Florida Agricultural and Mechanical University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Awards: RCMI Translational Research Network (RTRN), Center of Excellence for Cancer Research, Training and Community Service, FAMU RCMI Pharmaceutical Research Center, Pharmaceutical Research Center