Year: 2004
Type: article
Abstract: Magnetic Resonance Imaging is a non-invasive technique that has been developed for its excellent depiction of soft tissue contrasts.Instruments capable of ultra-high field strengths, ≥7 Tesla, were recently engineered and have resulted in higher signal-to-noise and higher resolution images.Total iron content within the brain is not homogenous.Age and a number of neurological conditions (such as Alzheimer's, Parkinson's, Multiple Sclerosis, etc.) may influence the distribution.The ability to non-invasively detect the distribution of iron may be useful for diagnosis and for assessment of the effectiveness of treatments.Iron is also capable of indirectly influencing the signal in an MRI study by dephasing spins.This may then lead to an increase in relaxation rates.However, the standard transverse relaxation rate is not the most sensitive measure of iron content and other methods, such as gradient echo, are plagued with artifacts (example: air-tissue susceptibility signal loss and distortion).To increase the sensitivity of high field spin echo analysis to the distribution of iron content, we have analyzed Hahn and CPMG spin echoes with the Carr and Purcell spin echo signal equation.This resulted in an intrinsic T2 xii Bloembergen-Purcell-Pound Theory ....
Author: Chastity Diane Shaffer Whitaker
Institution: The Ohio State University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W886870198