Work

Circulating RANKL/OPG in polymyalgia rheumatica.

Year: 2007

Type: article

Abstract: OBJECTIVE: To evaluate whether RANKL/OPG balance is modified in PMR patients, either in the active phase of the disease or during corticosteroid treatment. METHODS: Circulating levels of RANKL and OPG were assayed by enzyme-linked immunosorbent assay in PMR patients with active untreated disease and in patients treated by corticosteroids over a 12-month follow-up period. RESULTS: We found no statistically significant differences in circulating levels of OPG between PMR patients either in the active phase of the disease or during all follow-up period compared to normal controls. On the other hand, systemic production of sRANKL is increased and is not modulated by corticosteroid treatment. CONCLUSION: In PMR increased levels of sRANKL may be related to bone osteoporosis. Further investigations are necessary to evaluate the relationship between the RANK/RANKL/OPG system and bone turnover in PMR patients.

Source: PubMed

Authors: L Pulsatelli, P Dolzani, T Silvestri, L Boiardi, C Salvarani, P Macchioni, A Facchini, R Meliconi

Institutions: Istituto Ortopedico Rizzoli, University of Bologna, Santa Maria Nuova Hospital

Language: English

Topic: Vasculitis and related conditions

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W90217215

FWCI:

Cites: 14

Cited by: 2

Related to: 10