Year: 2013
Type: dissertation
Abstract: The WUTC Threshold Test is a new test of olfactory ability that focuses on the idea that deficits in olfactory ability are not necessarily generalizable to all odors. Though numerous diseases and disorders have been shown to lead to a loss of olfaction, tests of olfactory sensitivity have been limited to performance detecting a single odor. The WUTC is comprised of five odors that were selected based on differences in how they interact with the olfactory system and the chemical properties they possess. By utilizing a diverse odor profile, relationships between olfactory deficits to certain odors and specific diseases can be explored. The test also employs randomized, multiple presentation of odorants along with null-stimulus trials. Using this methodology, statistical measures of participant sensitivity, response-bias, threshold, and inter-rater reliability can be calculated with a single administration of the test. A pilot study, consisting of thirty three (N=33) participants, was conducted. Subject demographic data was also collected in order to conduct exploratory analyses and aid in the further development of the test. The reasoning and methodology of the WUTC Threshold test are discussed along with the analyses of the subject data. The results of this pilot study suggest that certain ailments do not have significant olfactory deficits to all odorants, only particular odor molecules. The principles behind the development of the WUTC Threshold Test may lead to the further understanding of links between olfaction and disease and an increase in the value of examining olfactory ability in a clinical setting.
Author: William A. Tewalt
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W902306375