Immunologic Approaches to the Therapy of Patients with HIV Infection
Year: 2001
Type: book-chapter
Abstract: The primary modality of therapy for patients with human immunodeficiency virus (HIV) infection is the use of combination antiretroviral chemotherapy to suppress HIV replication. As has been clearly established by a number of studies, effective suppression of HIV replication leads to an immediate improvement in immune function as evidenced by a marked decrease in opportunistic infections and increases in the naive and memory CD4 T cell pools (1–4). Unfortunately, it has also been clearly established that as a single approach, antiretroviral therapy only suppresses but does not eradicate HIV infection and thus life-long therapy is likely to be required in many patients (5). Given the concerns about long-term toxicities and the development of resistance there remains an interest in looking at alternatives to antiretroviral therapy alone. Immunologic approaches to therapy involve interventions that directly modulate the immune system.
Source: Humana Press eBooks
Authors: H. Clifford Lane, Scott Seeley
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W91072849