Work

A weighty problem: metabolic perturbations and the obesity-cancer link

Year: 2015

Type: review

Abstract: Obesity is an established risk factor for several cancers, including breast, colon, endometrial, ovarian, gastric, pancreatic and liver, and is increasingly a public health concern. Obese cancer patients often have poorer prognoses, reduced response to standard treatments, and are more likely to develop metastatic disease than normo-weight individuals. Many of the pathologic features of obesity promote tumor growth, such as metabolic perturbations, hormonal and growth factor imbalances, and chronic inflammation. Although obesity exacerbates tumor development, the interconnected relationship between the two conditions presents opportunities for new treatment approaches, some of which may be more successful in obese cohorts. Here, we discuss the many ways in which excess adiposity can impact cancer development and progression and address potential preventive and therapeutic strategies to reduce the burden of obesity-related cancers.

Source: Hormone Molecular Biology and Clinical Investigation

DOI: 10.1515/hmbci-2015-0022

Authors: Ciara H. O’Flanagan, Laura W. Bowers, Stephen D. Hursting

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Cancer Risks and Factors

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute