Work

Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis

Year: 1968

Type: article

Abstract: The effect of anti-gamma-globulin factors on 7S gamma-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-gamma-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S gamma-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human gammaG globulin. The antiopsonic effect of anti-gamma-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-gamma-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci105800

Authors: Ronald P. Messner, Throstur Laxdal, Paul G. Quie, Ralph C. Williams

Institution: University of Minnesota

Language: English

Topic: Infective Endocarditis Diagnosis and Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W92082012

FWCI: 12.34

Cites: 40

Cited by: 64

Related to: 10