Rho-family GTPase signaling in the nervous system : an analysis of the C. elegans RhoGEF UNC-73
Year: 2014
Type: article
Abstract: 73(Sec14) also develop more slowly compared to wildtype, but this phenotype may result from interference with the function of other Sec14 domain-containing proteins.These data point to the possible importance of the Sec14 domain in nervous system function and protein localization.To further characterize UNC-73 function, the unc-73c1 expression pattern was examined and a potential UNC-73C1 interaction with the Rab11 binding protein FIP-3/4 was characterized in vitro.UNC-73C1 localizes to a subset of neurons, including sensory neurons and interneurons, but not motorneurons.UNC-73C1 expression in these neurons rescues the unc-73 lethargic movement phenotype, indicating UNC-73 activity is required in upstream modulatory neurons to maintain a wild-type locomotion rate.Together, these results give us a better understanding of how the RhoGEF, UNC-73, functions in the nervous system and suggest new avenues for further study of UNC-73 homologs in mammals.v Acknowledgements First and foremost, I would like to thank my advisor, Dr. Robert Steven, for allowing
Author: Alyssa N. Hoop
Institution: University of Toledo
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W923272142