Intrinsic Field Homogeneity Correction in Fast Spin Echo based Amide Proton Transfer MRI
Year: 2012
Type: conference-paper
Abstract: Amide proton transfer (APT), a powerful technique for molecular imaging of endogenous proteins, is based on an asymmetry analysis of RFsaturation frequency offsets acquired around the water resonance, which needs precise B0 inhomogeneity correction. While fast spin-echo(FSE) based APT has superior contrast-to-noise ratio, the previouslyshown multi-echo APT acquisition with intrinsic Dixon-type B0 mapping is restricted to gradient-echo sequences. We propose a FSE-DixonAPT technique with varied echo time shifts, using iterative Dixon reconstruction across different positive saturation frequency offsetsfor intrinsic B0 mapping and correction. Feasibility in the human head is demonstrated using a clinical 3T scanner.
Authors: Jochen Keupp, Holger Eggers
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W92646007