The potential role of monocyte-lymphocyte interaction in arteriogenesis
Year: 2009
Type: dissertation
Abstract: Arteriogenesis (collateral vessel growth) is triggered by fluid shear stress in case of\nan arterial occlusion. It is an important focus in current cardiovascular research as\nit might provide new therapeutic opportunities. Although the molecular mechanisms\nunderlying arteriogenesis are not yet completely understood, it has been shown\nthat monocytes/macrophages and lymphocytes, in particular NK- and Tlymphocytes,\nplay an important role in arteriogenesis. The present literature study\nwas designed to gain more insight into the precise role of the latter cells in the\nonset and progression of collateral vessel growth and the interaction between both\ncell types. Based on the mechanistically similar process angiogenesis, in which the\ninflammatory response has been investigated in more detail, we suggest here that\nas a first step in the process of arteriogenesis lymphocytes interact with monocytes\nto trigger a cascade of biochemical processes eventually leading to collateral artery\ngrowth.
Author: Stijn Willems
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W94153032