Auswertung von Miktionssymptomen bei Prostatakarzinompatienten drei Jahre nach Therapie mit verschiedenen Behandlungsmethoden : eine prospektive Studie
Year: 2009
Type: dissertation
Study design: Observational Study
Abstract: Micturition symptoms are common complications that may occur in the course of a therapy for localised carcinoma of the prostate. Consequently these are sometimes hard to treat and impair affected patients physically, but these symptoms have an impact on health-related quality of life, as well. In this prospective thesis research was done on the influence of diverse epidemiological, socio-demographic and oncological parameters, as well as the pre-therapeutic evaluation of individual “Health related Quality of Life” (HRQOL) on micturition symptoms three years after a therapy. Longitudinal process observations were included and additionally categorized based on diverse therapy modalities. This approach is innovative, since as of today mostly merely retrospective studies exist. Furthermore, selected patients still suffering from incontinence symptoms after three years were interviewed on the phone. A total of 183 files from the “Aachen (Aix-la-Chapelle) Prostate Carcinoma Register“ (APCAR), were analyzed. From 1996 onwards, this register listed all patients suffering from prostate carcinoma treated at the Aachen university hospital. Questionnaires that included internationally acknowledged scores, such as the ICSmale and the EORTC, were distributed to interview these men at different points of time about parameters of urine incontinence and their quality of life. These data were correlated with outcome variables previously defined by us. Subsequently, process observations of improvements and degradations were compiled. After correlating the given data, it could be shown that post-therapeutic micturition symptoms three years after the therapy of local carcinoma of the prostate were mainly determined by the choice of the medical treatment (LUTS p=0.0491, Urgency p=0.0006) and, to a lesser degree, by pre-existing problems of incontinence (LUTS p=0.0001, Urgency p=0.0002). Pre-therapeutic data, tumor-descriptive and oncological parameters did not have any influence (all p>0.05). Likewise, the post-therapeutic micturition symptoms essentially influence the health-related quality of life from an opposing perspective. Moreover, the kind of treatment is responsible for the structure of longitudinal processes. With the help of the phone interviews it could be verified that for stressed patients with an ongoing post-therapeutic defiance of micturition symptoms, the implantations of an artificial sphincter should be employed as a valid therapy option for improving the status of incontinence after exhausting the conservative measures, especially when a patient still prefers treatment and shows his willingness to be operated on.
Source: RWTH Publications (RWTH Aachen)
Language: German
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W953253393