MicroRNA-19a promotes glioma cell growth by repressing LRIG1.
Year: 2014
Type: article
Abstract: Growing evidence indicates that deregulation of miRNAs contributes to the development of glioma. In present study, we found that the level of miRNA-19a was significantly elevated in glioma tissues and cell lines. Moreover, down-regulation of miRNA-19a dramatically repressed glioma cell growth in vitro and in vivo. Meanwhile, the expression of LRIG1, a tumor suppressor in glioma, was increased following miRNA-19a knockdown. Furthermore, luciferase reporter assay confirmed that LRIG1 was a direct target of miRNA-19a. In addition, silencing of LRIG1 could reverse the suppressive effect of miRNA-19a inhibitor. Taken together, our results demonstrated that down-regulation of miRNA-19a could suppress the growth of glioma cells, at least in part, through up-regulating LRIG1.
Source: PubMed
Authors: Ling-Min Shao, Ji-An Yang, Yue-Fei Wang, Peng Wu, Ji-Qiang Li, Qian-Xue Chen
Institution: Renmin Hospital of Wuhan University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W96464353