The effect of serum, glucocorticoids, gender and gestational age on the inactivation, synthesis and secretion of surfactant phospholipids by cultured foetal rat type II pneumocytes
Year: 2010
Type: dissertation
Abstract: Type II pneumocytes are responsible for the synthesis and secretion of pulmonary surfactant, which lines the alveoli of the lungs.Its presence as a monolayer at the airliquid interface in the alveoli diminishes surface tension, thus reducing the tendency of alveoli to collapse during expiration.For this effect to be sustained, however, the integrity of the surfactant components needs to be maintained.In this study it has been demonstrated that when cultured type II pneumocytes are exposed to lipoprotein-free serum (LFS) the level of lyso-phosphatidylcholine (lyso-PC) in the secreted surfactant phospholipids is elevated.The lyso-PC content of secreted phospholipids in serumsupplemented cultures increased 5.4-fold with a concomitant decline in the level of phosphatidylcholine (PC) when compared to cells grown in absence of LFS.This effect
Author: J Damas
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W981495998