Year: 2011
Type: article
Study design: Observational Study
Abstract: Objectives.To determine if, and to what extent maternal adipokines and glucose metabolism are associated with infant anthropometry at birth for obese and overweight pregnant mothers. Design. Prospective cohort studySubjects.Fifty-two healthy, non-smoking, overweight and obese pregnant women (pregravid BMI 25) between 18 and 40 years old were recruited from the greater Cincinnati metropolitan area.Methods.Pregravid body mass index (BMI= kg/m 2 ) was derived from self-reported anthropometric data.A fasting venous blood sample was collected at 26 weeks gestation to assess maternal adipokines and glucose metabolism.HOMA-IR was calculated from fasting glucose and insulin values.Infant anthropometry was self-reported by the mother following delivery.Fetal overgrowth was defined three ways; as macrosomia for infants JUDPV DW birth; as large-for-gestational-age (LGA) for birthweight 90 th percentile for gestational age, and as ponderal index 90 th percentile for weight-to-length ratio.Results.Infant ponderal index was positively correlated with maternal insulin concentration (r=+0.324,P<0.05) and HOMA-IR (r=+0.292,P<0.05).Maternal insulin explained 16% of the variance in ponderal index (R 2 = .16,F = 7.32, P < 0.01). Conclusion.Obese pregnant women have a metabolic profile similar to women diagnosed with gestational diabetes mellitus, and experience insulin resistance, inflammation, and the subsequent effects on fetal growth.Insulin resistance remains the most significant predictor of fetal overgrowth in this population.In this study, the maternal adipokines leptin, adiponectin, IL-6 and TNF-Į Zere not associated with infant anthropometry at birth.
Author: Alison Gardner
Institution: University of Cincinnati
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W99363644