The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.
Year: 2013
Type: article
Abstract: TP53 is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL). Modulation of microRNAs by TP53 in CLL pathogenesis has been a hotspot. Besides, it has an intimate association with other cytogenetics and plays an important part in drug resistance of CLL. All above indicate an embedded TP53-centered network in CLL pathogenesis and prognosis. In this review, we focus on the TP53-centered network and its roles in the pathogenesis of CLL.
Source: Europe PMC (PubMed Central)
Authors: Cheng Wang, Xin Wang
Institutions: Shandong University, Shandong Provincial Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W99697349