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Andrew D. Huber

Observed names: A. Huber, A.D. Huber, Andrew D Huber, Andrew Huber, Huber, Andrew Douglas
ORCID: 0000-0002-3790-8368
Observed ORCID: 0000-0002-3790-8368
OpenAlex ID: A5000406538
4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms
2014 · Eleftherios Michailidis, Andrew D. Huber, et al. · Journal of Biological Chemistry · 118
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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5
2020 · William C. Wright, Jude Chenge, et al. · Journal of Medicinal Chemistry · 60
Multiplex single-cell visualization of nucleic acids and protein during HIV infection
2017 · Maritza Puray-Chavez, Philip R. Tedbury, et al. · Nature Communications · 50
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Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond
2022 · Shyaron Poudel, Andrew D. Huber, et al. · Drug Metabolism and Disposition · 46
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Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H
2017 · Jayakanth Kankanala, Karen A. Kirby, et al. · European Journal of Medicinal Chemistry · 45
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
2022 · Monicah N Bwayi, Efren Garcia-Maldonado, et al. · Nucleic Acids Research · 44
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Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity
2017 · Sanjeev Kumar V. Vernekar, Jing Tang, et al. · Journal of Medicinal Chemistry · 44
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H
2016 · Bulan Wu, Jing Tang, et al. · Journal of Medicinal Chemistry · 44
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
2013 · Eleftherios Michailidis, Emily M Ryan, et al. · Retrovirology · 38
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6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity
2018 · Lei Wang, Jing Tang, et al. · European Journal of Medicinal Chemistry · 35
SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1
2022 · Andrew D. Huber, Yongtao Li, et al. · ACS Medicinal Chemistry Letters · 34
Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning
2020 · Andrew D. Huber, William C. Wright, et al. · Cellular and Molecular Life Sciences · 34
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H
2018 · Lei Wang, Jing Tang, et al. · European Journal of Medicinal Chemistry · 32
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The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells
2018 · Andrew D. Huber, Jennifer J. Wolf, et al. · mSphere · 32
SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase Inhibitors
2014 · Andrew D. Huber, Eleftherios Michailidis, et al. · Antimicrobial Agents and Chemotherapy · 32
CITCO Directly Binds to and Activates Human Pregnane X Receptor
2019 · Wenwei Lin, Monicah Bwayi, et al. · Molecular Pharmacology · 31
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Regulation of PXR in drug metabolism: chemical and structural perspectives
2024 · Rebecca R. Florke Gee, Andrew D. Huber, et al. · Expert Opinion on Drug Metabolism & Toxicology · 29
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Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase
2017 · Jing Tang, Sanjeev Kumar V. Vernekar, et al. · European Journal of Medicinal Chemistry · 28
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker
2019 · Jing Tang, Ha T. Do, et al. · European Journal of Medicinal Chemistry · 27
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase
2017 · Jing Tang, Karen A. Kirby, et al. · European Journal of Medicinal Chemistry · 27
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5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors
2018 · Jing Tang, Andrew D. Huber, et al. · European Journal of Medicinal Chemistry · 26
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
2024 · Efren Garcia-Maldonado, Andrew D. Huber, et al. · Nature Communications · 25
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H
2017 · Andrew D. Huber, Eleftherios Michailidis, et al. · Antimicrobial Agents and Chemotherapy · 24
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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein
2023 · Wenwei Lin, Andrew D. Huber, et al. · Proceedings of the National Academy of Sciences · 21
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5
2021 · Jingheng Wang, Cameron D. Buchman, et al. · Journal of the American Chemical Society · 21
Works count: 60
Citation count: 1,105
H-index: 23
I10-index: 34
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