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Nikolaus Schiering

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
2006 · Paul Erbel, Nikolaus Schiering, et al. · Nature Structural & Molecular Biology · 598
Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607
1991 · N. Schiering, W. Kabsch, et al. · Nature · 203
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
2003 · Nikolaus Schiering, Stefan Knapp, et al. · Proceedings of the National Academy of Sciences · 162
Iron, DtxR, and the regulation of diphtheria toxin expression
1994 · Xu Tao, Nikolaus Schiering, et al. · Molecular Microbiology · 144
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans
2019 · Alexander W. Koch, Nikolaus Schiering, et al. · Blood · 136
Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae.
1995 · N Schiering, X Tao, et al. · Proceedings of the National Academy of Sciences · 93
Identification of the primary metal ion-activation sites of the diphtheria tox represser by X-ray crystallography and site-directed mutational analysis
1996 · X. Ding, H. Zeng, et al. · Nature Structural & Molecular Biology · 86
Direct Renin Inhibitors as a New Therapy for Hypertension
2010 · Randy L. Webb, Nikolaus Schiering, et al. · Journal of Medicinal Chemistry · 75
Structure of neprilysin in complex with the active metabolite of sacubitril
2016 · Nikolaus Schiering, Allan D’Arcy, et al. · Scientific Reports · 69
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Dimer Formation through Domain Swapping in the Crystal Structure of the Grb2-SH2−Ac-pYVNV Complex
2000 · Nikolaus Schiering, Elena Casale, et al. · Biochemistry · 66
A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target
2011 · Nikolaus Schiering, Allan D’Arcy, et al. · Proceedings of the National Academy of Sciences · 58
Fragment-Based Screening by Biochemical Assays: Systematic Feasibility Studies with Trypsin and MMP12
2010 · Andreas Boettcher, Simon Ruedisser, et al. · SLAS DISCOVERY · 46
Combined use of computational chemistry, NMR screening, and X‐ray crystallography for identification and characterization of fluorophilic protein environments
2010 · Anna Vulpetti, Nikolaus Schiering, et al. · Proteins Structure Function and Bioinformatics · 38
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach
2020 · Edwige Lorthiois, James Roache, et al. · Journal of Medicinal Chemistry · 29
Purification, Crystallization, and Preliminary X-ray Diffraction Studies of the Flavoenzyme Mercuric Ion Reductase from Bacillus sp. Strain RC607
1989 · M J Moore, M D Distefano, et al. · Journal of Biological Chemistry · 28
Regulation of the Wild-Type and Y1235D Mutant Met Kinase Activation
2005 · Cinzia Cristiani, Luisa Rusconi, et al. · Biochemistry · 22
Differential inhibition sensitivities of MET mutants to the small molecule inhibitor SU11274
2009 · Yitzhak Zimmer, Angelina V. Vaseva, et al. · Cancer Letters · 21
Purification and crystallization of dengue and West Nile virus NS2B–NS3 complexes
2006 · Allan D'Arcy, Maxime Chaillet, et al. · Acta Crystallographica Section F Structural Biology and Crystallization Communications · 21
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Trypsin inhibitors for the treatment of pancreatitis
2016 · Trixi Brandl, Oliver Simic, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors
2014 · Takeru Ehara, Osamu Irie, et al. · ACS Medicinal Chemistry Letters · 17
Efficient Screening of Target‐Specific Selected Compounds in Mixtures by 19F NMR Binding Assay with Predicted 19F NMR Chemical Shifts
2022 · Anna Vulpetti, Andreas Lingel, et al. · ChemMedChem · 12
Crystallization and Preliminary X-ray Studies of the Diphtheria Tox Repressor from Corynebacterium diphtheriae
1994 · Nikolaus Schiering, Xu Tao, et al. · Journal of Molecular Biology · 12
Fluorescence Lifetime–Based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro
2014 · Andreas Boettcher, Nathalie Gradoux, et al. · SLAS DISCOVERY · 11
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors
2020 · Toshio Kawanami, Rajeshri G. Karki, et al. · ACS Medicinal Chemistry Letters · 10
Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity
2020 · Nicola Hughes, Paul Erbel, et al. · Advanced Therapeutics · 8
Works count: 45
Citation count: 1,995
H-index: 19
I10-index: 24
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