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Rouven Hoefflin

Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours
2023 · Avishai Gavish, Michael Tyler, et al. · Nature · 544
Integrative spatial analysis reveals a multi-layered organization of glioblastoma
2024 · Alissa C. Greenwald, Noam Galili Darnell, et al. · Cell · 396
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HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
2020 · Rouven Hoefflin, Sabine Harlander, et al. · Nature Communications · 290
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Personalized Clinical Decision Making Through Implementation of a Molecular Tumor Board: A German Single-Center Experience
2018 · Rouven Hoefflin, Anna-Lena Geißler, et al. · JCO Precision Oncology · 107
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
2016 · Rouven Hoefflin, Bernd Lahrmann, et al. · Nature Communications · 77
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A spatial expression atlas of the adult human proximal small intestine
2024 · Yotam Harnik, Oran Yakubovsky, et al. · Nature · 68
Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis
2021 · Rouven Hoefflin, Adriana Lazarou, et al. · Cancers · 57
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Emerging clinical applications of single-cell RNA sequencing in oncology
2025 · Emily Boxer, Nisan Feigin, et al. · Nature Reviews Clinical Oncology · 46
The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution
2025 · Michael Tyler, Avishai Gavish, et al. · Nature Cancer · 35
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
2024 · Dominik Schmidt, Cornelia Endres, et al. · Cancer Research · 23
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A spatial atlas of the healthy human liver from live donors
2026 · Oran Yakubovsky, Keren Bahar Halpern, et al. · Nature · 22
Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation—Immune signature correlates with response
2023 · Petya Apostolova, Stefanie Kreutmair, et al. · British Journal of Haematology · 19
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ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma
2022 · Philipp Seidel, Anne Rubarth, et al. · JCI Insight · 16
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Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma
2021 · Rouven Hoefflin, Sabine Harlander, et al. · Cancers · 16
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Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma
2014 · Meike Schneider, Julia Schüler, et al. · Urologic Oncology Seminars and Original Investigations · 12
The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution
2024 · Michael Tyler, Avishai Gavish, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 11
A blueprint for local and distal invasion programs in glioblastoma
2026 · Rony Chanoch-Myers, Toshiro Hara, et al. · Nature Communications · 6
Intratumorale Heterogenität des Nierenzellkarzinoms
2015 · R. Höfflin, W. Roth, et al. · Der Urologe · 5
Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance
2025 · Asin Peighambari, Hsin Huang, et al. · Scientific Reports · 3
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Primary Results of Patients with Genitourinary Malignancies Presented at a Molecular Tumor Board
2024 · Jakob Michaelis, Ruth Himmelsbach, et al. · Urologia Internationalis · 2
Spatial analysis reveals the evolving organization of IDH-mutant glioma
2026 · Rouven Hoefflin, Alissa C. Greenwald, et al. · Cancer Cell · 1
Characterisation of TP53 mutational features and outcomes of acute myeloid leukaemia after allogeneic haematopoietic cell transplantation
2026 · Martina Reuss, Thomas Meyer, et al. · Bone Marrow Transplantation
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Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas
2026 · Depro Das, Alina Pandele, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Abstract 1982: Genomic analyses of patient-derived xenografts reveal novel molecular subsets of PDAC and their association with clinical features.
2026 · Chani Stossel, Rotem Tal, et al. · Cancer Research
A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroid
2026 · Yael Korem Kohanim, Tal Barkai, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Works count: 39
Citation count: 1,757
H-index: 14
I10-index: 17
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