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Ana S. Newton

Observed names: A.S. Newton, Ana Newton, Ana Sofia Newton, Newton, Ana S
Institution: Yale University
ORCID: 0000-0002-0196-0869
Observed ORCID: 0000-0002-0196-0869
OpenAlex ID: A5008097653
Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity
2014 · Marta P. Carrasco, Ana S. Newton, et al. · European Journal of Medicinal Chemistry · 83
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders
2017 · David E. Puleo, Kaury Kucera, et al. · ACS Medicinal Chemistry Letters · 48
An Endoperoxide‐Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites
2013 · Rudi Oliveira, Ana S. Newton, et al. · ChemMedChem · 40
Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure–activity study
2010 · Ana S. Newton, Paulo M.C. Glória, et al. · European Journal of Medicinal Chemistry · 40
JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules
2017 · Ana S. Newton, Luca Deiana, et al. · ACS Medicinal Chemistry Letters · 33
Alkyl deoxy-arabino-hexopyranosides: Synthesis, surface properties, and biological activities
2008 · Filipa V.M. Silva, Margarida Goulart, et al. · Bioorganic & Medicinal Chemistry · 32
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core
2020 · Maria-Elena Liosi, Stefan G. Krimmer, et al. · Journal of Medicinal Chemistry · 29
Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway
2011 · Paulo M.C. Glória, Isabel Coutinho, et al. · European Journal of Medicinal Chemistry · 29
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands
2022 · Maria-Elena Liosi, Joseph A. Ippolito, et al. · Journal of Medicinal Chemistry · 28
Metadynamics as a Postprocessing Method for Virtual Screening with Application to the Pseudokinase Domain of JAK2
2020 · Kara J. Cutrona, Ana S. Newton, et al. · Journal of Chemical Information and Modeling · 28
Structure-Guided Identification of DNMT3B Inhibitors
2020 · Ana S. Newton, John C. Faver, et al. · ACS Medicinal Chemistry Letters · 21
Novel anti-Plasmodial hits identified by virtual screening of the ZINC database
2013 · Grace Mugumbate, Ana S. Newton, et al. · Journal of Computer-Aided Molecular Design · 21
Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant
2021 · Ana S. Newton, Maria-Elena Liosi, et al. · Tetrahedron Letters · 13
Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies
2022 · Sean P. Henry, Maria-Elena Liosi, et al. · ACS Medicinal Chemistry Letters · 12
Substituent effects on O–H and S–H bond dissociation enthalpies of disubstituted phenols and thiophenols
2007 · Daniel J. V. A. dos Santos, Ana S. Newton, et al. · International Journal of Quantum Chemistry · 12
Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor
2017 · Thomas K. Dawson, Pawel Dziedzic, et al. · ACS Medicinal Chemistry Letters · 11
Orchestrating a Highly Interactive Virtual Student Research Symposium
2020 · Jessica G. Freeze, Jessica A. Martin, et al. · Journal of Chemical Education · 10
Covalent Modification of the JH2 Domain of Janus Kinase 2
2022 · Sean P. Henry, Maria-Elena Liosi, et al. · ACS Medicinal Chemistry Letters · 8
Engineering diaminotriazole ligands into ATP-mimetics for selective targeting of the Janus kinase 2 (JAK2) pseudokinase domain (JH2)
2021 · Maria-Elena Liosi, Stefan Krimmer, et al.
JAK2 JH2 in complex with JAK064
2020 · D.E. Puleo, S.G. Krimmer, et al. · Worldwide Protein Data Bank
Design, synthesis, and evaluation of peptidyl inhibitors for clan CA and clan CD cysteine proteases
2013 · Ana S. Newton · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Design of caspase-3 inhibitors as potential therapeutic agents
2009 · Ana S. Newton, Daniel JVAdos Santos, et al. · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Vinyl Sulfones as Caspase Inhibitors
2009 · Maria M. M. Santos, Ana S. Newton, et al. · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Vinylsulfones as potential caspase inhibitors
2008 · Santos, Maria MM, Newton, Ana S, et al. · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Works count: 24
Citation count: 498
H-index: 13
I10-index: 17
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