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Christine A. Hough
Observed names:
C. HOUGH,
C. Hough,
Christine Hough
Institutions:
University of Ferrara,
Queen's University
Observed institutions:
University of Calgary,
University of Ferrara,
Queen's University,
Centre Hospitalier Universitaire Sainte-Justine,
University of Southampton,
Nara Medical University
show all 6
ORCID:
0000-0001-5663-4801
Observed ORCID:
0000-0001-5663-4801
OpenAlex ID:
A5008809031
The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study
2006
·
Paula D. James
, Colleen Notley
, et al.
·
Blood
·
363
PDF
Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs
2001
·
Angela M. Gallo-Penn
, Pamela S. Shirley
, et al.
·
Blood
·
112
Ex Vivo Gene Therapy for Hemophilia A That Enhances Safe Delivery and Sustained In Vivo Factor VIII Expression from Lentivirally Engineered Endothelial Progenitors
2007
·
Hideto Matsui
, Masaru Shibata
, et al.
·
Stem Cells
·
105
Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease
2003
·
Lee A. O'Brien
, Paula D. James
, et al.
·
Blood
·
97
PDF
Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4+CD25+-dependent mechanism and by shifting cytokine production to favor a Th1 response
2008
·
Braden Waters
, Mohammad Qadura
, et al.
·
Blood
·
85
PDF
Aberrant Splicing and Premature Termination of Transcription of the FVIII Gene as a Cause of Severe Canine Hemophilia A: Similarities with the Intron 22 Inversion Mutation in Human Hemophilia
2002
·
Christine Hough
, Seiki Kamisue
, et al.
·
Thrombosis and Haemostasis
·
83
A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A
2011
·
Hideto Matsui
, Carol Hegadorn
, et al.
·
Molecular Therapy
·
78
PDF
The Canine Factor VIII cDNA and 5’ Flanking Sequence
1998
·
Cherie Cameron
, Colleen Notley
, et al.
·
Thrombosis and Haemostasis
·
74
Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice
2009
·
Mohammad Qadura
, Braden Waters
, et al.
·
Blood
·
67
A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells
2009
·
Hideto Matsui
, Masaru Shibata
, et al.
·
Blood
·
60
PDF
Biological considerations of plasma-derived and recombinant factor VIII immunogenicity
2017
·
Jesse Lai
, Christine Hough
, et al.
·
Blood
·
51
PDF
Factors influencing therapeutic efficacy and the host immune response to helper‐dependent adenoviral gene therapy in hemophilia A mice
2004
·
B.D. Brown
, C.X. Shi
, et al.
·
Journal of Thrombosis and Haemostasis
·
48
In Vivo Evaluation of an Adenoviral Vector Encoding Canine Factor VIII: High-Level, Sustained Expression in Hemophiliac Mice
1999
·
Angela M. Gallo-Penn
, Pamela S. Shirley
, et al.
·
Human Gene Therapy
·
46
Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells
2008
·
M. QADURA
, M. OTHMAN
, et al.
·
Journal of Thrombosis and Haemostasis
·
44
Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C2 domain
2006
·
F.E. RAWLE
, K.P. PRATT
, et al.
·
Journal of Thrombosis and Haemostasis
·
44
PDF
Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies
2016
·
T.C. Nichols
, C. Hough
, et al.
·
Journal of Thrombosis and Haemostasis
·
42
An assessment of the pathogenic significance of the R924Q von Willebrand factor substitution
2009
·
E. BERBER
, P.D. JAMES
, et al.
·
Journal of Thrombosis and Haemostasis
·
42
Long-term follow-up of liver-directed, adeno-associated vector-mediated gene therapy in the canine model of hemophilia A
2022
·
P. Batty
, A. M. Mo
, et al.
·
Blood
·
38
PDF
Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice
2010
·
M. QADURA
, B. WATERS
, et al.
·
Haemophilia
·
38
PDF
Influence of a GT repeat element on shear stress responsiveness of the VWF gene promoter
2008
·
C. HOUGH
, C.L. CAMERON
, et al.
·
Journal of Thrombosis and Haemostasis
·
36
PDF
Gene therapy for hemophilia: an imperative to succeed
2005
·
C. HOUGH
, D. LILLICRAP
·
Journal of Thrombosis and Haemostasis
·
35
PDF
Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A
2016
·
Jesse D. Lai
, Paul C. Moorehead
, et al.
·
Blood
·
33
PDF
The Canine Factor VIII 3′-Untranslated Region and a Concatemeric Hepatocyte Nuclear Factor 1 Regulatory Element Enhance Factor VIII Transgene Expression In Vivo
2002
·
Colleen Notley
, Annie Killoran
, et al.
·
Human Gene Therapy
·
32
Heterogeneity of the immune response to adenovirus‐mediated factor VIII gene therapy in different inbred hemophilic mouse strains
2004
·
Fiona E. M. Rawle
, Chang Xin Shi
, et al.
·
The Journal of Gene Medicine
·
31
N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice
2018
·
Jesse D. Lai
, Laura L. Swystun
, et al.
·
Haematologica
·
30
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Works count:
61
Citation count:
1,953
H-index:
27
I10-index:
35
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