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Nicole E. Scharping

Observed names: Nicole E. Scharping, Nicole E Scharping, Nicole Scharping, Nicole E. Scharping
Observed institutions: University of Pittsburgh, University of California San Diego, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Western Fisheries Research Center, Seattle Children's Research Institute
ORCID: 0000-0001-9373-4617
Observed ORCID: 0000-0001-9373-4617
OpenAlex ID: A5010917930
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
2021 · Nicole E. Scharping, Dayana B. Rivadeneira, et al. · Nature Immunology · 882
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
2016 · Nicole E. Scharping, Ashley V. Menk, et al. · Immunity · 832
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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
2016 · Nicole E. Scharping, Ashley V. Menk, et al. · Immunity · 706
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CD8+ T cell metabolism in infection and cancer
2021 · Miguel Reina-Campos, Nicole E. Scharping, et al. · Nature reviews. Immunology · 612
Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia
2016 · Nicole E. Scharping, Ashley V. Menk, et al. · Cancer Immunology Research · 518
Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions
2018 · Ashley V. Menk, Nicole E. Scharping, et al. · Cell Reports · 484
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4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
2018 · Ashley V. Menk, Nicole E. Scharping, et al. · The Journal of Experimental Medicine · 313
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Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
2022 · Paolo D. A. Vignali, Kristin DePeaux, et al. · Nature Immunology · 267
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B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
2016 · Shaun W. Jackson, Holly M. Jacobs, et al. · The Journal of Experimental Medicine · 207
Opposing Impact of B Cell–Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation
2014 · Shaun W Jackson, Nicole E Scharping, et al. · The Journal of Immunology · 165
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells
2021 · Ilkka Liikanen, Colette Lauhan, et al. · Journal of Clinical Investigation · 150
Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity
2016 · Nicole Scharping, Greg Delgoffe · Vaccines · 120
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Roles of Inflammatory Caspases during Processing of Zebrafish Interleukin-1β in Francisella noatunensis Infection
2012 · Lucia N. Vojtech, Nicole Scharping, et al. · Infection and Immunity · 111
Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells
2022 · B. Rhodes Ford, Paolo D. A. Vignali, et al. · Science Immunology · 109
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted
2025 · Miguel Reina-Campos, Alexander Monell, et al. · Nature · 99
IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell
2019 · Lulu Shao, Weizhou Hou, et al. · Cancer Immunology Research · 90
Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells
2016 · Holly M Jacobs, Christopher D Thouvenel, et al. · The Journal of Immunology · 52
Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation
2016 · Shaun W Jackson, Nicole E Scharping, et al. · The Journal of Immunology · 48
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Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
2021 · J. Justin Milner, Clara Toma, et al. · The Journal of Experimental Medicine · 38
B‐cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott–Aldrich syndrome
2015 · Nikita S. Kolhatkar, Nicole E. Scharping, et al. · European Journal of Immunology · 20
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
2016 · Casey Ager, Matthew Reilley, et al. · Journal for ImmunoTherapy of Cancer · 17
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The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity
2024 · Amir Ferry, Kianoosh M. Mempel, et al. · The Journal of Experimental Medicine · 15
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
2016 · Andreas Lundqvist, Vincent van Hoef, et al. · Journal for ImmunoTherapy of Cancer · 11
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743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
2025 · Nicole E. Scharping, Xuezhen Ge, et al. · Cell · 7
Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer
2021 · B. Rhodes Ford, Natalie L. Rittenhouse, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 6
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Works count: 77
Citation count: 5,921
H-index: 20
I10-index: 25
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