Get started
Author

Anna Jirkovská

Observed names: A Jirkovska, A Jirkovska-Vavrova, A. JIRKOVSKÁ, A. Jirkovska, Anna Jirkovska, Anna Jirkovská-Vávrová, Anna Vavrova, Anna Vávrová, Jirkovska A, Jirkovska, Anna, Jirkovská, Anna
Institution: Charles University
ORCID: 0000-0002-0131-6010
Observed ORCID: 0000-0002-0131-6010
OpenAlex ID: A5011664065
Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection
2012 · Martin Štěrba, Olga Popelová, et al. · Antioxidants and Redox Signaling · 329
Catalytic Inhibitors of Topoisomerase II Differently Modulate the Toxicity of Anthracyclines in Cardiac and Cancer Cells
2013 · Anna Vavrova, Hana Jansova, et al. · PLoS ONE · 75
PDF
Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury
2010 · Petra Bendova, Eliska Mackova, et al. · Chemical Research in Toxicology · 72
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation
2021 · Eduard Jirkovský, Anna Jirkovská, et al. · Circulation Heart Failure · 64
PDF
Synthesis and Initial in Vitro Evaluations of Novel Antioxidant Aroylhydrazone Iron Chelators with Increased Stability against Plasma Hydrolysis
2011 · Katerina Hruskova, Petra Kovarikova, et al. · Chemical Research in Toxicology · 56
Chronic Anthracycline Cardiotoxicity: Molecular and Functional Analysis with Focus on Nuclear Factor Erythroid 2-Related Factor 2 and Mitochondrial Biogenesis Pathways
2012 · Eduard Jirkovský, Olga Popelová, et al. · Journal of Pharmacology and Experimental Therapeutics · 55
Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity
2010 · Pavlína Hašková, Petra Kovaříková, et al. · Free Radical Biology and Medicine · 49
Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action
2012 · Eliška Macková, Kateřina Hrušková, et al. · Chemico-Biological Interactions · 46
Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity
2011 · Pavlína Hašková, Lucie Koubková, et al. · Toxicology · 40
Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury
2014 · Hana Jansová, Miloslav Macháček, et al. · Free Radical Biology and Medicine · 30
Quantitative Analysis of the Anti-Proliferative Activity of Combinations of Selected Iron-Chelating Agents and Clinically Used Anti-Neoplastic Drugs
2014 · Eliska Potuckova, Hana Jansova, et al. · PLoS ONE · 30
PDF
Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite
2017 · Jan Bures, Anna Jirkovska, et al. · Toxicology · 27
Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model
2015 · Juraj Lenčo, Olga Lenčová-Popelová, et al. · Experimental Cell Research · 27
In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity
2010 · Anna Vávrová, Olga Popelová, et al. · Archives of Toxicology · 27
Structure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties
2014 · Eliška Potůčková, Kateřina Hrušková, et al. · PLoS ONE · 24
PDF
DNA topoisomerase IIβ: A player in regulation of gene expression and cell differentiation
2012 · Anna Vávrová, Tomáš Šimůnek · The International Journal of Biochemistry & Cell Biology · 24
Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions
2021 · Anna Jirkovská, Galina Karabanovich, et al. · Journal of Medicinal Chemistry · 22
Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart
2017 · Eduard Jirkovský, Anna Jirkovská, et al. · Journal of Pharmacology and Experimental Therapeutics · 22
PDF
Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo
2015 · Anna Jirkovská-Vávrová, Jaroslav Roh, et al. · Toxicology Research · 22
Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane
2015 · Olga Lenčová-Popelová, Eduard Jirkovský, et al. · Journal of Molecular and Cellular Cardiology · 21
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβ Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity
2020 · Petra Kollárová-Brázdová, Anna Jirkovská, et al. · Journal of Pharmacology and Experimental Therapeutics · 20
PDF
Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using 55Fe and storage phosphorimaging
2018 · M. Krijt, A. Jirkovska, et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 19
Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection
2025 · Jan Kubeš, Galina Karabanovich, et al. · Nature Communications · 18
PDF
Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury
2016 · Pavlína Hašková, Hana Jansová, et al. · Toxicology · 18
In vitro and in vivo investigation of cardiotoxicity associated with anticancer proteasome inhibitors and their combination with anthracycline
2019 · Zuzana Pokorna, Eduard Jirkovsky, et al. · Clinical Science · 15
Works count: 49
Citation count: 1,213
H-index: 20
I10-index: 27
Year
Topic
Type